Supporting real-time data traffic in safety-critical, vehicle-to-infrastructure communication

communicatio

A reliable token-based MAC protocol for delay sensitive platooning applications

© 2015 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.Platooning is both a challenging and rewarding application. Challenging since strict timing and reliability requirements are imposed by the distributed control system required to operate the platoon. Rewarding since considerable fuel reductions are possible. As platooning takes place in a vehicular ad hoc network, the use of IEEE 802.11p is close to mandatory. However, the 802.11p medium access method suffers from packet collisions and random delays. Most ongoing research suggests using TDMA on top of 802.11p as a potential remedy. However, TDMA requires synchronization and is not very flexible if the beacon frequency needs to be updated, the number of platoon member changes or if retransmissions for increased reliability are required. We therefore suggest a token-passing medium access method where the next token holder is selected based on beacon data age. This has the advantage of allowing beacons to be re-broadcasted in each beacon interval whenever time and bandwidth is available. We show that our token-based method is able to reduce the data age and increase reliability considerably compared to pure 802.11p.This work was partially supported by the Ministerio de Ciencia e Innovación, Spain, under Grant TIN2011-27543- C03-01. Balador is funded by ERASMUS+ programme, and Böhm and Uhlemann are also funded by the Knowledge Foundation through the ACDC projectBalador, A.; Böhm, A.; Uhlemann, E.; Tavares De Araujo Cesariny Calafate, CM.; Cano Escribá, JC. (2015). A reliable token-based MAC protocol for delay sensitive platooning applications. IEEE. https://doi.org/10.1109/VTCFall.2015.7390813

Critical, Engaged and Change-oriented Scholarship in Environmental Communication. Six Methodological Dilemmas to Think With

While calls for critical, engaged and change-oriented scholarship in environmental communication (EC) abound, few articles discuss what this may practically entail. With this article, we aim to contribute to a discussion in EC about the methodological implications of such scholarship. Based on our combined experience in EC research and drawing from a variety of academic fields, we describe six methodological dilemmas that we encounter in our research practice and that we believe are inherent to such scholarship. These dilemmas are (1) grasping communication; (2) representing others; (3) involving people in research; (4) co-producing knowledge; (5) engaging critically; and (6) relating to conflict. This article does not offer solutions to these complex dilemmas. Rather, our dilemma descriptions are meant to help researchers think through methodological issues in critical, engaged and change-oriented EC research. The article also helps to translate the dilemmas to the reality of research projects through a set of questions, aimed to support a sensitivity to, and understanding of, the dilemmas in context. critical, engaged, change-oriented, methodology, dillemmaspublishedVersio

Prevention, screening, assessing and managing of non-adherent behaviour in people with rheumatic and musculoskeletal diseases: Systematic reviews informing the 2020 EULAR points to consider

© Objective To analyse how non-adherence to prescribed treatments might be prevented, screened, assessed and managed in people with rheumatic and musculoskeletal diseases (RMDs). Methods An overview of systematic reviews (SR) was performed in four bibliographic databases. Research questions focused on: (1) effective interventions or strategies, (2) associated factors, (3) impact of shared decision making and effective communication, (4) practical things to prevent non-adherence, (5) effect of non-adherence on outcome, (6) screening and assessment tools and (7) responsible healthcare providers. The methodological quality of the reviews was assessed using AMSTAR-2. The qualitative synthesis focused on results and on the level of evidence attained from the studies included in the reviews. Results After reviewing 9908 titles, the overview included 38 SR on medication, 29 on non-pharmacological interventions and 28 on assessment. Content and quality of the included SR was very heterogeneous. The number of factors that may influence adherence exceed 700. Among 53 intervention studies, 54.7% showed a small statistically significant effect on adherence, and all three multicomponent interventions, including different modes of patient education and delivered by a variety of healthcare providers, showed a positive result in adherence to medication. No single assessment provided a comprehensive measure of adherence to either medication or exercise. Conclusions The results underscore the complexity of non-adherence, its changing pattern and dependence on multi-level factors, the need to involve all stakeholders in all steps, the absence of a gold standard for screening and the requirement of multi-component interventions to manage it

RANTES/CCL5 and Risk for Coronary Events: Results from the MONICA/KORA Augsburg Case-Cohort, Athero-Express and CARDIoGRAM Studies

BACKGROUND: The chemokine RANTES (regulated on activation, normal T-cell expressed and secreted)/CCL5 is involved in the pathogenesis of cardiovascular disease in mice, whereas less is known in humans. We hypothesised that its relevance for atherosclerosis should be reflected by associations between CCL5 gene variants, RANTES serum concentrations and protein levels in atherosclerotic plaques and risk for coronary events. METHODS AND FINDINGS: We conducted a case-cohort study within the population-based MONICA/KORA Augsburg studies. Baseline RANTES serum levels were measured in 363 individuals with incident coronary events and 1,908 non-cases (mean follow-up: 10.2±4.8 years). Cox proportional hazard models adjusting for age, sex, body mass index, metabolic factors and lifestyle factors revealed no significant association between RANTES and incident coronary events (HR [95% CI] for increasing RANTES tertiles 1.0, 1.03 [0.75-1.42] and 1.11 [0.81-1.54]). None of six CCL5 single nucleotide polymorphisms and no common haplotype showed significant associations with coronary events. Also in the CARDIoGRAM study (>22,000 cases, >60,000 controls), none of these CCL5 SNPs was significantly associated with coronary artery disease. In the prospective Athero-Express biobank study, RANTES plaque levels were measured in 606 atherosclerotic lesions from patients who underwent carotid endarterectomy. RANTES content in atherosclerotic plaques was positively associated with macrophage infiltration and inversely associated with plaque calcification. However, there was no significant association between RANTES content in plaques and risk for coronary events (mean follow-up 2.8±0.8 years). CONCLUSIONS: High RANTES plaque levels were associated with an unstable plaque phenotype. However, the absence of associations between (i) RANTES serum levels, (ii) CCL5 genotypes and (iii) RANTES content in carotid plaques and either coronary artery disease or incident coronary events in our cohorts suggests that RANTES may not be a novel coronary risk biomarker. However, the potential relevance of RANTES levels in platelet-poor plasma needs to be investigated in further studies

RANTES/CCL5 and risk for coronary events: Results from the MONICA/KORA Augsburg case-cohort, Athero-express and CARDIoGRAM studies

Background: The chemokine RANTES (regulated on activation, normal T-cell expressed and secreted)/CCL5 is involved in the pathogenesis of cardiovascular disease in mice, whereas less is known in humans. We hypothesised that its relevance for atherosclerosis should be reflected by associations between CCL5 gene variants, RANTES serum concentrations and protein levels in atherosclerotic plaques and risk for coronary events. Methods and Findings: We conducted a case-cohort study within the population-based MONICA/KORA Augsburg studies. Baseline RANTES serum levels were measured in 363 individuals with incident coronary events and 1,908 non-cases (mean follow-up: 10.2±

The trans-ancestral genomic architecture of glycemic traits

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 x 10(-8)), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution. A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.Peer reviewe

State of the Art on Energy-Efficient and Latency-Constrained Networking Protocols for Wireless Sensor Networks

Advances in the development and integration of small battery-powered sensing devices have enabled the design of applications where a group of sensors cooperate in monitoring their environment. Wireless sensor networks (WSN) are today used in a wide variety of areas like e.g. habitat monitoring, battle field surveillance, disaster management, health monitoring or industrial control. Their applicability is often reduced by limitations in the sensor nodes power supply, communication bandwidth, processing capabilities and buffer size. Many researchers have put effort in overcoming these shortcomings, with a special focus on maximizing the battery lifetime of a single node as well as the lifetime of the network as a whole. A list of possible applications can be found in [Akyildiz]. As applications become more and more mission-critical, it is crucial that the collected sensor data arrive at the sink within a specified time limit. Guaranteeing a certain quality of service (QoS) to a user or an application is difficult because of the unpredictable nature of the wireless link and the often unstable topology of the sensor network (due to node failure or mobility). Very little research has been done in the field of QoS for WSNs [Chen] [Wang] and many interesting research questions are still unanswered. This state-of-the-art document aims at giving an overview on routing and medium access issues in WSNs and at summarizing some of the most interesting solutions. The requirements on WSN protocols are very dependent on the application in which the WSN will be used. Aspects as energy-efficiency, latency, Quality of Service (QoS), mobility, distribution density or cost all influence the choice of protocol and its parameters. There is therefore no single protocol that matches all types of WSN and the best results can only be achieved by tailoring the protocol for a specific application or scenario. In this state-of-the-art report, we make certain assumptions, loosely based upon the requirements of a surveillance application